Efficacy and Safety Evaluation

TOA offers a variety of efficacy evaluation tests and safety
evaluation tests that can objectively measure the effects on the skin.

Efficacy Evaluation

We conduct various evaluation tests on not only raw materials but also cosmetic products at the cellular and human levels. For human evaluation tests, we have constant-temperature and constant-humidity rooms at Skin Research Center and Yokohama Laboratory respectively in order to provide a suitable environment for measurements. We propose an appropriate test method according to your request.

Skin care area
  • Evaluation for moisturizing and epidermal barrier functions
  • Aging care assessment
  • Evaluation for skin penetration
Makeup area
  • Evaluation for long-wearing effect
  • Evaluation for makeup performance
  • Coloration evaluation
Organoleptic area
  • Rheology and Application feel
  • Odor evaluation
  • Evaluation of warm and cool sensations

Safety Evaluation

We have introduced non-animal safety tests to evaluate the safety of raw materials and cosmetic products. We’re capable of performing a variety of testing methods including methods according to internationally-recognized OECD guidelines, our own in-house standards as well as testing arrangements to verify the safety for sensitive skin.

Primary skin irritation test
  • Test method using reconstructed human epidermis:
    OECD TG439
Eye irritation test
  • Short-Term Exposure (STE):
    OECD TG491
  • Test method using reconstructed human corneal-like epithelial model:
    OECD TG492
Skin sensitization test
  • Amino Acid Derivative Reactivity Assay (ADRA):
    OECD TG442C
  • Human Cell Line Activation Test (h-CLAT):
    OECD TG442E
Phototoxicity test
  • 3T3 NRU Phototoxicity Test:
    OECD TG432